Surface Plasmon Resonance (SPR) is an established method for biomolecular interaction analysis. It is popular due to its sensitivity and its real-time label-free principle. Multi-Parametric Surface Plasmon Resonance (MP-SPR) is based on SPR theory, however its advantageous optical setup measures a full SPR curve which enables new insight into interactions.
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MP-SPR Navi™
Details
Category:
Life Science – Lab Instrument – MP-SPR
Manufacture:
BioNavis Ltd – Finland
| Measuring principle: | Multi-Parametric SPR based on a true goniometric SPR arrangement with a rotating laser |
| Angular range: | 40 -78 degree real angular resolution 0.001˚. |
| Laser Set: | Optional 670nm, 785nm, 850 nm and 980 nm |
| Liquid handling: | 2 and 4 separate flow channels (depends on models). Controlled buffer flow conditions with precise syringe pumps and integrated degasser |
| Dynamic range: | 38000 mdeg |
| Temperature Range in flow-cell: | 15-45°C |
| Measurement range: | ka 10^3-10^8 M^-1 Sec^-1; kd 10^-7-0.1 Sec^-1; KD = 10^3 – 10^12 M |
| RI range: | 1.00 – 1.40 |
- With PureKinetics™ feature for high quality kinetics, MP-SPR is a powerful and sensitive tool for direct measurements of small molecules.
- MP-SPR helps you to measure biomembrane interaction kinetics as well as underlying structural changes.
- MP-SPR is an excellent choice for drug delivery studies – from real-time targeting studies to real-time internalization with the same instrument.
- MP-SPR enables to move from drug-target measurements, through drug-membrane interactions all the way to drug-cell interactions
- Antibody-antigen interaction affinity and kinetic measurements can be performed in diverse liquids including complex liquids such as serum or saliva
- MP-SPR can be combined with electrochemistry to measure catalytic interactions, electroswitching surfaces and also to develop electrochemical biosensors.
- MP-SPR measures interactions on polymers up to 5 µm thick, which makes it the most sensitive label-free technique for biomaterial interaction studies and layer characterization
- Antibody characterization through drug uptake routes, controlled drug release strategies, small molecule measurements, nanoparticle targeting up to drug internalization by living cell
- MP-SPR characterization of nanoparticle interaction with a lipid bilayer and with liposomes
- Drug delivery, with nano particle
| Catalog No. | Description |
| SPR420A-ILVES | MP-SPR Navi 420A ILVES scientific instrument |
| SPR220A-NAALI | MP-SPR Navi 220A NAALI scientific instrument |
| SPR210A-VASA | MP-SPR Navi 210A VASA scientific instrument |
| SPR400-KONTIO | MP-SPR Navi 400 KONTIO scientific instrument |
| SPR200-OTSO | MP-SPR Navi 200 OTSO scientific instrument |
- Biomolecule affinity and concentration studies
- In-situ capture of T-cells and analysis of membrane receptor affinity with biofunctionalized lipid sensor
- Biosensor for bacteria detection from powdered milk
- Nanoparticle uptake by cells measured using MP-SPR
- Faster interaction measurements using MP-SPR KineticTitration
- Analyzing dissociation kinetics of IgG from protein A using MP-SPR and PureKinetics™
- Small molecular weight drug-protein interaction measured with MP-SPR
- Real-time monitoring of antibody binding by parallel MP-SPR, potentiometry and impedance spectroscopy
- Antibody and antigen interaction measured with MP-SPR
